Clinical features of elderly-onset Adult-onset Still's disease.
Mod Rheumatol
; 31(4): 862-868, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-32990106
ABSTRACT
OBJECTIVES:
To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).METHODS:
Patients were classified into elderly-onset (>60 years 47 patients) and younger-onset (≤60 years 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.RESULTS:
In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p < .0001), whereas pleuritis (27.7% vs 7.4%, respectively; p = .0011) and disseminated intravascular coagulation (19.1% vs 2.1%, respectively; p = .0004) were more frequent, and serum ferritin levels were higher (median 12,700 ng/ml vs 2526 ng/ml, respectively; p < .0001). Overall survival and AOSD-related survival were reduced (p = .0006 and p = .0023, respectively) and drug-free remission was less frequent (p = .0035) in the elderly-onset group compared with the younger-onset group.CONCLUSIONS:
Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Still del Adulto
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mod Rheumatol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón