Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-&#954;B and MAPK mediated apoptosis signaling pathways in mice.

Wang, Shuang; Tang, Shan; Chen, Xuan; Li, Xin; Jiang, Shuang; Li, Hui-Ping; Jia, Pin-Hui; Song, Ming-Jie; Di, Peng; Li, Wei

Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice.

Wang, Shuang; Tang, Shan; Chen, Xuan; Li, Xin; Jiang, Shuang; Li, Hui-Ping; Jia, Pin-Hui; Song, Ming-Jie; Di, Peng; Li, Wei.

Afiliación

Wang S; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Tang S; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Chen X; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Li X; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Jiang S; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China.
Li HP; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China.
Jia PH; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Song MJ; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China.
Di P; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China. Electronic address: dipeng@outlook.com.
Li W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun, 130118, China. Electronic address: liwei7727@126.com.

Chem Biol Interact ; 331: 109233, 2020 Nov 01.

Article en En | MEDLINE | ID: mdl-32991863

Asunto(s)

Lesión Renal Aguda/patología; Apoptosis/efectos de los fármacos; Sustancias Protectoras/farmacología; Transducción de Señal/efectos de los fármacos; Lesión Renal Aguda/inducido químicamente; Lesión Renal Aguda/veterinaria; Animales; Cisplatino/toxicidad; Modelos Animales de Enfermedad; Interleucina-1beta/metabolismo; Riñón/efectos de los fármacos; Riñón/metabolismo; Riñón/patología; Masculino; Ratones; Ratones Endogámicos ICR; Proteínas Quinasas Activadas por Mitógenos/metabolismo; FN-kappa B/metabolismo; Fosforilación; Sustancias Protectoras/química; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Apoptosis; Cisplatin; MAPK; NF-κB; Nephrotoxicity; Pulchinenoside B4

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Apoptosis / Sustancias Protectoras / Lesión Renal Aguda Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Chem Biol Interact Año: 2020 Tipo del documento: Article País de afiliación: China

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