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Gold Nanoclusters for NIR-II Fluorescence Imaging of Bones.
Li, Deling; Liu, Qiang; Qi, Qingrong; Shi, Hui; Hsu, En-Chi; Chen, Weiyu; Yuan, Wenli; Wu, Yifan; Lin, Sien; Zeng, Yitian; Xiao, Zunyu; Xu, Lingyun; Zhang, Yanrong; Stoyanova, Tanya; Jia, Wang; Cheng, Zhen.
Afiliación
  • Li D; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Liu Q; College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu, Sichuan, 610041, China.
  • Qi Q; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Shi H; West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
  • Hsu EC; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Chen W; Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, 94304, USA.
  • Yuan W; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Wu Y; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Lin S; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Zeng Y; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
  • Xiao Z; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
  • Xu L; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Zhang Y; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, Palo Alto, CA, 94305, USA.
  • Stoyanova T; Department of Materials Science and Engineering, Stanford University, Palo Alto, CA, 94304, USA.
  • Jia W; Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, CA, 94304, USA.
  • Cheng Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Small ; 16(43): e2003851, 2020 10.
Article en En | MEDLINE | ID: mdl-33000882
ABSTRACT
Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR-II probes is crucial for realizing the medical applications of NIR-II fluorescence imaging. Herein, the glutathione-capped gold nanoclusters (AuNCs, specifically Au25 (SG)18 ) demonstrate highly efficient binding capability to hydroxyapatite in vitro for the first time. Further in vivo NIR-II fluorescence imaging of AuNCs indicate that they accumulate in bone tissues with high contrast and signal-background ratio. AuNCs are also mainly and quickly excreted from body through renal system, showing excellent ribs and thoracic vertebra imaging because of no background signal in liver and spleen. The deep tissue penetration capability and high resolution of AuNCs in NIR-II imaging render their great potential for fluorescence-guided surgery like spinal pedicle screw implantation. Overall, AuNCs are highly promising and clinical translatable NIR-II imaging probe for visualizing bone and bone related abnormalities.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Oro Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Oro Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China