<i>N</i>-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal ß-Glucocerebrosidase.

Wolfsgruber, Andreas; Thonhofer, Martin; Weber, Patrick; Nasseri, Seyed A; Fischer, Roland; Schalli, Michael; Stütz, Arnold E; Withers, Stephen G; Wrodnigg, Tanja M

N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal ß-Glucocerebrosidase.

Wolfsgruber, Andreas; Thonhofer, Martin; Weber, Patrick; Nasseri, Seyed A; Fischer, Roland; Schalli, Michael; Stütz, Arnold E; Withers, Stephen G; Wrodnigg, Tanja M.

Afiliación

Wolfsgruber A; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Thonhofer M; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Weber P; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Nasseri SA; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Fischer R; Institute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Schalli M; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Stütz AE; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
Withers SG; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Wrodnigg TM; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.

Molecules ; 25(20)2020 Oct 11.

Article en En | MEDLINE | ID: mdl-33050585

Asunto(s)

Glucosilceramidasa/metabolismo; Lisosomas/enzimología; Ácido Benzoico/metabolismo; Humanos; Cinética; Espectroscopía de Resonancia Magnética; Estructura Molecular

Palabras clave

N-alkylated iminosugars; glycomimetics; inhibitors for ß-glucocerebrosidase; tools for glycoprocessing enzymes; ß-glucosidase inhibitors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glucosilceramidasa / Lisosomas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Austria

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