The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence.
Environ Res
; 195: 110313, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33069699
ABSTRACT
Phthalates are ubiquitous environmental chemicals with predominantly anti-androgenic, and potentially obesogenic effects. We hypothesised that antenatal phthalate exposure may influence subsequent boy's growth and body composition through childhood and adolescence. Among 1399 singleton males from the Raine Study, 410 had maternal serum and at least one height, BMI or DEXA outcome available after birth and up to 20 years of age. Maternal serum collected at 18 and 34 weeks' gestation was pooled, and analyzed for concentrations of 32 metabolites of 15 phthalate diesters. Their serum concentrations were categorized into undetectable/detectable levels or tertiles. Linear mixed models were used to determine associations between maternal serum phthalate levels and longitudinal height and body mass index (BMI) z-scores in boys from birth to 20 years of age (nâ¯=â¯250 and nâ¯=â¯295 respectively). Linear regression was used to determine associations between maternal phthalate levels and deviation from mid-parental height (nâ¯=â¯177) and DEXA scan outcomes (nâ¯=â¯191) at the 20 year follow-up. Weak positive associations of participants height z-score increase were detected with exposure to some phthalate metabolites in particular to the lower molecular weight phthalate metabolites. Less consistent findings, by mixed model analyses, were detected for BMI and body composition, by dual energy X-ray absorptiometry (DEXA), with some positive associations of phthalate metabolites with BMI and some negative associations with DEXA fat tissue measures, although no consistent findings were evident. In conclusion, we derived some associations of childhood growth with prenatal phthalate exposure, particularly with respect to the lower molecular weight phthalate metabolites.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácidos Ftálicos
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Efectos Tardíos de la Exposición Prenatal
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Contaminantes Ambientales
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Environ Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia