Cell Migration: Deconstructing the Matrix.

Elosegui-Artola, Alberto; Oria, Roger

Elosegui-Artola, Alberto; Oria, Roger.

Afiliación

Elosegui-Artola A; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Cambridge, MA, USA; Institute for Bioengineering of Catalonia, Barcelona, Spain. Electronic address: aelosegui@seas.harvard.edu.
Oria R; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: roger.oriafernandez@ucsf.edu.

Curr Biol ; 30(20): R1266-R1268, 2020 10 19.

Article en En | MEDLINE | ID: mdl-33080198

ABSTRACT

ABSTRACT

New work identifies a mechanism of cell migration whereby cellular mechanical forces dissociate extracellular matrix (ECM) ligands from the substrate. The local dissociation of ECM ligands creates an ECM ligand gradient below the cell body that guides cellular migration.

Asunto(s)

Matriz Extracelular; Integrinas; Movimiento Celular; Matriz Extracelular/metabolismo; Integrinas/metabolismo; Ligandos; Transporte de Proteínas

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Integrinas / Matriz Extracelular Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article

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