Impact of intraoperative goal-directed fluid therapy on major morbidity and mortality after transthoracic oesophagectomy: a multicentre, randomised controlled trial.
Br J Anaesth
; 125(6): 953-961, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33092805
ABSTRACT
BACKGROUND:
Transthoracic oesophagectomy is associated with major morbidity and mortality, which may be reduced by goal-directed therapy (GDT). The aim of this multicentre, RCT was to evaluate the impact of intraoperative GDT on major morbidity and mortality in patients undergoing transthoracic oesophagectomy.METHODS:
Adult patients undergoing transthoracic oesophagectomy were randomised to receive either minimally invasive intraoperative GDT (stroke volume variation <8%, plus systolic BP maintained >90 mm Hg by pressors as necessary) or haemodynamic management left to the discretion of attending senior anaesthetists (control group; systolic BP >90 mm Hg alone). The primary outcome was the incidence of death or major complications (reoperation for bleeding, anastomotic leakage, pneumonia, reintubation, >48 h ventilation). A Cox proportional hazard model was used to examine whether the effects of GDT on morbidity and mortality were independent of other potential confounders.RESULTS:
A total of 232 patients (80.6% male; age range 36-83 yr) were randomised to either GDT (n=115) or to the control group (n=117). After surgery, major morbidity and mortality were less frequent in 22/115 (19.1%) subjects randomised to GDT, compared with 41/117 (35.0%) subjects assigned to the control group {absolute risk reduction 15.9% (95% confidence interval [CI] 4.7-27.2%); P=0.006}. GDT was also associated with fewer episodes of atrial fibrillation (odds ratio [OR] 0.18 [95% CI 0.05-0.65]), respiratory failure (OR 0.27 [95% CI 0.09-0.83]), use of mini-tracheotomy (OR 0.29 [95% CI 0.10-0.81]), and readmission to ICU (OR 0.09 [95% CI 0.01-0.67]). GDT was independently associated with morbidity and mortality (hazard ratio 0.51 [95% CI 0.30-0.87]; P=0.013).CONCLUSIONS:
Intraoperative GDT may reduce major morbidity and mortality, and shorten hospital stay, after transthoracic oesophagectomy. CLINICAL TRIAL REGISTRATION UMIN000018705.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
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Esofagectomía
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Fluidoterapia
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Cuidados Intraoperatorios
Tipo de estudio:
Clinical_trials
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Observational_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Br J Anaesth
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón