Phosphatidylinositol-4-kinase II&#945; licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells.

López-Haber, Cynthia; Levin-Konigsberg, Roni; Zhu, Yueyao; Bi-Karchin, Jing; Balla, Tamas; Grinstein, Sergio; Marks, Michael S; Mantegazza, Adriana R

Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells.

López-Haber, Cynthia; Levin-Konigsberg, Roni; Zhu, Yueyao; Bi-Karchin, Jing; Balla, Tamas; Grinstein, Sergio; Marks, Michael S; Mantegazza, Adriana R.

Afiliación

López-Haber C; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Levin-Konigsberg R; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Zhu Y; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Bi-Karchin J; Division of Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Balla T; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Grinstein S; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Marks MS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Mantegazza AR; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Proc Natl Acad Sci U S A ; 117(45): 28251-28262, 2020 11 10.

Article en En | MEDLINE | ID: mdl-33109721

Asunto(s)

1-Fosfatidilinositol 4-Quinasa/metabolismo; Células Dendríticas/inmunología; Complejo Mayor de Histocompatibilidad/fisiología; Fagosomas/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Células de la Médula Ósea; Citocinas/metabolismo; Lipopolisacáridos; Ratones; Transducción de Señal; Receptor Toll-Like 4/genética; Receptores Toll-Like/metabolismo

Palabras clave

AP-3; MHC-II; PI4KIIα; TIRAP; dendritic cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Dendríticas / Fagosomas / 1-Fosfatidilinositol 4-Quinasa / Receptor Toll-Like 4 / Complejo Mayor de Histocompatibilidad Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

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