Alamandine through MrgD receptor induces antidepressant-like effect in transgenic rats with low brain angiotensinogen.
Horm Behav
; 127: 104880, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33129833
ABSTRACT
Alamandine (Ala1-Arg2-Val3-Tyr4-Ile5-His6-Pro7), a heptapeptide hormone of the renin-angiotensin system (RAS), exerts its effects through the Mas-related G-protein coupled receptor of the type D, MrgD, which is expressed in different tissues, including the brain. In the present study, we tested the hypothesis that alamandine could attenuate the depression-like behavior observed in transgenic rats with low brain angiotensinogen, TGR (ASrAOGEN)680. Transgenic rats exhibited a significant increase in the immobility time in forced swim test, a phenotype reversed by intracerebroventricular infusion of alamandine. Pretreatment with D-Pro7-Ang-(1-7), a Mas/MrgD receptor antagonist, prevented the antidepressant-like effect induced by this peptide demonstrating, for the first time, that alamandine through MrgD receptor, can modulate depression-like behavior in TGR (ASrAOGEN)680. This result shows an action of alamandine which strengthens the importance of the counter-regulatory arms of the RAS in fight and treatment of neuropsychiatric diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Encéfalo
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Angiotensinógeno
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Receptores Acoplados a Proteínas G
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Antidepresivos
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Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Horm Behav
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil