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Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures?
Theilmann, Wiebke; Brandt, Claudia; Bohnhorst, Bettina; Winstroth, Anne-Mieke; Das, Anibh Martin; Gramer, Martina; Kipper, Andi; Kalesse, Markus; Löscher, Wolfgang.
Afiliación
  • Theilmann W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Brandt C; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Bohnhorst B; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
  • Winstroth AM; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
  • Das AM; Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
  • Gramer M; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Kipper A; Institute for Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany.
  • Kalesse M; Institute for Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany.
  • Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.
Epilepsia ; 62(1): 269-278, 2021 01.
Article en En | MEDLINE | ID: mdl-33140458
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Bumetanida / Profármacos / Esterasas / Ésteres Límite: Animals / Female / Humans / Male / Newborn Idioma: En Revista: Epilepsia Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Bumetanida / Profármacos / Esterasas / Ésteres Límite: Animals / Female / Humans / Male / Newborn Idioma: En Revista: Epilepsia Año: 2021 Tipo del documento: Article País de afiliación: Alemania