Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms.

Xie, Chunfang; Slagboom, Julien; Albulescu, Laura-Oana; Somsen, Govert W; Vonk, Freek J; Casewell, Nicholas R; Kool, Jeroen

Xie, Chunfang; Slagboom, Julien; Albulescu, Laura-Oana; Somsen, Govert W; Vonk, Freek J; Casewell, Nicholas R; Kool, Jeroen.

Afiliación

Xie C; Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Slagboom J; Centre for Analytical Sciences Amsterdam (CASA), Amsterdam 1098 XH, The Netherlands.
Albulescu LO; Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Somsen GW; Centre for Analytical Sciences Amsterdam (CASA), Amsterdam 1098 XH, The Netherlands.
Vonk FJ; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Casewell NR; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Kool J; Amsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.

Acta Pharm Sin B ; 10(10): 1835-1845, 2020 Oct.

Article en En | MEDLINE | ID: mdl-33163338

Palabras clave

ACN, acetonitrile; Antivenom; CTL, C-type lectins; Chelators; DMSO, dimethyl sulfoxide; Dimercaprol; FA, formic acid; HTS, high-throughput screening; LC, liquid chromatography; MS, mass spectrometry; Marimastat; NOI, no observed inhibition; Nanofractionation; PBS, phosphate buffered saline; PLA2, phospholipase A2; PN, partly neutralised at 20 µmol/L inhibitor concentrations; SVMP, snake venom metalloproteinase; SVSP, snake venom serine protease; Snakebite; TIC, total ion current; Varespladib; WHO, World Health Organization; XIC, extracted ion current

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

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