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COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database.
Korn, Daniel; Bobrowski, Tesia; Li, Michael; Kebede, Yaphet; Wang, Patrick; Owen, Phillips; Vaidya, Gaurav; Muratov, Eugene; Chirkova, Rada; Bizon, Chris; Tropsha, Alexander.
Afiliación
  • Korn D; Department of Computer Science, University of North Carolina at Chapel Hill, USA.
  • Bobrowski T; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
  • Li M; Department of Computer Science, University of North Carolina at Chapel Hill, USA.
  • Kebede Y; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7568, USA.
  • Wang P; CoVar Applied Technologies, Durham, NC 27701, USA.
  • Owen P; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7568, USA.
  • Vaidya G; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7568, USA.
  • Muratov E; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
  • Chirkova R; Department of Computer Science, North Carolina State University, Raleigh, NC 27606-5550, USA.
  • Bizon C; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7568, USA.
  • Tropsha A; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Bioinformatics ; 37(4): 586-587, 2021 05 01.
Article en En | MEDLINE | ID: mdl-33175089
ABSTRACT

SUMMARY:

In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action. AVAILABILITY AND IMPLEMENTATION COVID-KOP is freely accessible at https//covidkop.renci.org/. For code and instructions for the original ROBOKOP, see https//github.com/NCATS-Gamma/robokop.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos