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Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers.
Choi, Du-Bong; Choi, Hansol; Lee, Jihoon; Lee, Yeon-Ju; Lee, Hyi-Seung; Joo, Jung Min; Lee, Jong Seok.
Afiliación
  • Choi DB; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr and Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan, Republic of Korea.
  • Choi H; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr.
  • Lee J; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr and Department of Applied Ocean Science, Korea University of Science and Technology, Daejeon, Republic of Korea.
  • Lee YJ; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr and Department of Applied Ocean Science, Korea University of Science and Technology, Daejeon, Republic of Korea.
  • Lee HS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr and Department of Applied Ocean Science, Korea University of Science and Technology, Daejeon, Republic of Korea.
  • Joo JM; Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan, Republic of Korea.
  • Lee JS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea. jslee@kiost.ac.kr and Department of Applied Ocean Science, Korea University of Science and Technology, Daejeon, Republic of Korea.
Org Biomol Chem ; 18(45): 9227-9230, 2020 11 25.
Article en En | MEDLINE | ID: mdl-33179693
ABSTRACT
We describe a divergent and enantioselective total synthesis of (+)-ieodomycin A and (+)-ieodomycin B with three stereoisomers. The main advantage of the present synthesis is the late-stage elaboration of the side chain, which would afford a wide range of structurally diverse analogs with interesting bioactivities.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article