Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL.

Anand, Praveen; Guillaumet-Adkins, Amy; Dimitrova, Valeriya; Yun, Huiyoung; Drier, Yotam; Sotudeh, Noori; Rogers, Anna; Ouseph, Madhu M; Nair, Monica; Potdar, Sayalee; Isenhart, Randi; Kloeber, Jake A; Vijaykumar, Tushara; Niu, Leili; Vincent, Tiffaney; Guo, Guangwu; Frede, Julia; Harris, Marian H; Place, Andrew E; Silverman, Lewis B; Teachey, David T; Lane, Andrew A; DeAngelo, Daniel J; Aster, Jon C; Bernstein, Bradley E; Lohr, Jens G; Knoechel, Birgit

Anand, Praveen; Guillaumet-Adkins, Amy; Dimitrova, Valeriya; Yun, Huiyoung; Drier, Yotam; Sotudeh, Noori; Rogers, Anna; Ouseph, Madhu M; Nair, Monica; Potdar, Sayalee; Isenhart, Randi; Kloeber, Jake A; Vijaykumar, Tushara; Niu, Leili; Vincent, Tiffaney; Guo, Guangwu; Frede, Julia; Harris, Marian H; Place, Andrew E; Silverman, Lewis B; Teachey, David T; Lane, Andrew A; DeAngelo, Daniel J; Aster, Jon C; Bernstein, Bradley E; Lohr, Jens G; Knoechel, Birgit.

Afiliación

Anand P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Guillaumet-Adkins A; Broad Institute of MIT and Harvard, Cambridge, MA.
Dimitrova V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Yun H; Broad Institute of MIT and Harvard, Cambridge, MA.
Drier Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Sotudeh N; Broad Institute of MIT and Harvard, Cambridge, MA.
Rogers A; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Ouseph MM; Broad Institute of MIT and Harvard, Cambridge, MA.
Nair M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Potdar S; Broad Institute of MIT and Harvard, Cambridge, MA.
Isenhart R; Department of Pathology, Massachusetts General Hospital, Boston, MA.
Kloeber JA; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Vijaykumar T; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Niu L; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Vincent T; Department of Pathology, Brigham and Women's Hospital, Boston, MA.
Guo G; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Frede J; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Harris MH; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Place AE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Silverman LB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Teachey DT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Lane AA; Children's Hospital of Philadelphia, Philadelphia, PA; and.
DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Aster JC; Broad Institute of MIT and Harvard, Cambridge, MA.
Bernstein BE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.
Lohr JG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Knoechel B; Broad Institute of MIT and Harvard, Cambridge, MA.

Blood ; 137(18): 2463-2480, 2021 05 06.

Article en En | MEDLINE | ID: mdl-33227818

Asunto(s)

Carcinogénesis; Galectinas/metabolismo; Regulación Leucémica de la Expresión Génica; Evasión Inmune; Células Madre Neoplásicas/patología; Leucemia-Linfoma Linfoblástico de Células T Precursoras/patología; Análisis de la Célula Individual/métodos; Adolescente; Adulto; Anciano; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Niño; Preescolar; Resistencia a Antineoplásicos; Femenino; Estudios de Seguimiento; Galectinas/genética; Receptor 2 Celular del Virus de la Hepatitis A/genética; Receptor 2 Celular del Virus de la Hepatitis A/metabolismo; Humanos; Lactante; Masculino; Persona de Mediana Edad; Mutación; Células Madre Neoplásicas/inmunología; Células Madre Neoplásicas/metabolismo; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/inmunología; Leucemia-Linfoma Linfoblástico de Células T Precursoras/metabolismo; Pronóstico; RNA-Seq/métodos; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto; Adulto Joven

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Regulación Leucémica de la Expresión Génica / Galectinas / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Evasión Inmune / Análisis de la Célula Individual / Carcinogénesis Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Blood Año: 2021 Tipo del documento: Article País de afiliación: Marruecos

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