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Focal adhesion kinase (FAK) inhibitor-defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream molecular network.
Zhang, Lingyuan; Zhao, Di; Wang, Yan; Zhang, Weimin; Zhang, Jing; Fan, Jiawen; Zhan, Qimin; Chen, Jie.
Afiliación
  • Zhang L; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zhao D; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Wang Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zhang W; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zhang J; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Fan J; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zhan Q; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Chen J; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China.
Mol Carcinog ; 60(2): 113-124, 2021 02.
Article en En | MEDLINE | ID: mdl-33283357
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Sulfonamidas / Benzamidas / Neoplasias Esofágicas / Carcinoma de Células Escamosas / Transducción de Señal / Ensayos Antitumor por Modelo de Xenoinjerto / Proteína-Tirosina Quinasas de Adhesión Focal / Redes Reguladoras de Genes Límite: Animals / Female / Humans Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Sulfonamidas / Benzamidas / Neoplasias Esofágicas / Carcinoma de Células Escamosas / Transducción de Señal / Ensayos Antitumor por Modelo de Xenoinjerto / Proteína-Tirosina Quinasas de Adhesión Focal / Redes Reguladoras de Genes Límite: Animals / Female / Humans Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China