Spreading of Isolated <i>Ptch</i> Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.

Brandes, Nadine; Mitkovska, Slavica Hristomanova; Botermann, Dominik Simon; Maurer, Wiebke; Müllen, Anna; Scheile, Hanna; Zabel, Sebastian; Frommhold, Anke; Heß, Ina; Hahn, Heidi; Uhmann, Anja

Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.

Brandes, Nadine; Mitkovska, Slavica Hristomanova; Botermann, Dominik Simon; Maurer, Wiebke; Müllen, Anna; Scheile, Hanna; Zabel, Sebastian; Frommhold, Anke; Heß, Ina; Hahn, Heidi; Uhmann, Anja.

Afiliación

Brandes N; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Mitkovska SH; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Botermann DS; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Maurer W; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Müllen A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Scheile H; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Zabel S; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Frommhold A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Heß I; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Hahn H; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Uhmann A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.

Int J Mol Sci ; 21(23)2020 Dec 05.

Article en En | MEDLINE | ID: mdl-33291515

Asunto(s)

Carcinoma Basocelular/genética; Carcinoma Basocelular/patología; Transformación Celular Neoplásica/genética; Mutación; Receptor Patched-1/genética; Factores de Edad; Animales; Carcinoma Basocelular/metabolismo; Susceptibilidad a Enfermedades; Células Epidérmicas/metabolismo; Células Epidérmicas/patología; Técnica del Anticuerpo Fluorescente; Técnicas de Sustitución del Gen; Genes Reporteros; Folículo Piloso/metabolismo; Folículo Piloso/patología; Humanos; Inmunohistoquímica; Inmunofenotipificación; Ratones; Ratones Transgénicos; Receptor Patched-1/metabolismo; Piel/metabolismo; Piel/patología; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/metabolismo; Células Madre/metabolismo; Células Madre/patología

Palabras clave

Patched receptor; basal cell carcinoma; epidermal cells; epidermis; hair follicle; keratin 5

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Basocelular / Transformación Celular Neoplásica / Receptor Patched-1 / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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