Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones.

Smith, Richard H; Chen, Yun-Ching; Seifuddin, Fayaz; Hupalo, Daniel; Alba, Camille; Reger, Robert; Tian, Xin; Araki, Daisuke; Dalgard, Clifton L; Childs, Richard W; Pirooznia, Mehdi; Larochelle, Andre

Smith, Richard H; Chen, Yun-Ching; Seifuddin, Fayaz; Hupalo, Daniel; Alba, Camille; Reger, Robert; Tian, Xin; Araki, Daisuke; Dalgard, Clifton L; Childs, Richard W; Pirooznia, Mehdi; Larochelle, Andre.

Afiliación

Smith RH; Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chen YC; Laboratory of Bioinformatics and Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Seifuddin F; Laboratory of Bioinformatics and Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hupalo D; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Alba C; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Reger R; Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Tian X; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20814, USA.
Araki D; Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Dalgard CL; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Childs RW; Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pirooznia M; Laboratory of Bioinformatics and Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Larochelle A; Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Genes (Basel) ; 11(12)2020 12 13.

Article en En | MEDLINE | ID: mdl-33322084

Asunto(s)

Sistemas CRISPR-Cas; Cromosomas Humanos Par 19/genética; Cromosomas Humanos Par 2/genética; Células Clonales; Edición Génica; Células Madre Hematopoyéticas; Adulto; Femenino; Sitios Genéticos; Humanos; Receptores CXCR4/genética

Palabras clave

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9); off-target activity; whole genome sequencing (WGS)

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 2 / Cromosomas Humanos Par 19 / Células Madre Hematopoyéticas / Células Clonales / Sistemas CRISPR-Cas / Edición Génica Límite: Adult / Female / Humans Idioma: En Revista: Genes (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google