Clinical relevance of brain atrophy subtypes categorization in memory clinics.
Alzheimers Dement
; 17(4): 641-652, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33325121
ABSTRACT
INTRODUCTION:
The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown.METHODS:
A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms.RESULTS:
Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups.DISCUSSION:
Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Atrofia
/
Encéfalo
/
Enfermedad de Alzheimer
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Instituciones de Atención Ambulatoria
/
Trastornos de la Memoria
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimers Dement
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia