[Research progresses on PGC-1α, a key energy metabolic regulator].
Sheng Li Xue Bao
; 72(6): 804-816, 2020 Dec 25.
Article
en Zh
| MEDLINE
| ID: mdl-33349839
ABSTRACT
Disturbance of the energy balance, when the energy intake exceeds its expenditure, is a major risk factor for the development of metabolic syndrome (MS). The peroxisome proliferator activated receptor γ (PPARγ) coactivator-1α (PGC-1α) functions as a key regulator of energy metabolism and has become a hotspot in current researches. PGC-1α sensitively responds to the environmental stimuli and nutrient signals, and further selectively binds to different transcription factors to regulate various physiological processes, including glucose metabolism, lipid metabolism, and circadian clock. In this review, we described the gene and protein structure of PGC-1α, and reviewed its tissue-specific function in the regulation of energy homeostasis in various mammalian metabolic organs, including liver, skeletal muscle and heart, etc. At the meanwhile, we summarized the application of potential small molecule compounds targeting PGC-1α in the treatment of metabolic diseases. This review will provide theoretical basis and potential drug targets for the treatment of metabolic diseases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Metabolismo Energético
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2020
Tipo del documento:
Article
País de afiliación:
China