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Pharmacokinetic and Pharmacodynamic Modeling of Tezepelumab to Guide Phase 3 Dose Selection for Patients With Severe Asthma.
Ly, Neang; Zheng, Yanan; Griffiths, Janet M; van der Merwe, Rene; Agoram, Balaji; Parnes, Jane R; Roskos, Lorin.
Afiliación
  • Ly N; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R and D, AstraZeneca, South San Francisco, California, USA.
  • Zheng Y; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R and D, AstraZeneca, South San Francisco, California, USA.
  • Griffiths JM; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R and D, AstraZeneca, Gaithersburg, Maryland, USA.
  • van der Merwe R; Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R and D, AstraZeneca, Cambridge, UK.
  • Agoram B; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R and D, AstraZeneca, South San Francisco, California, USA.
  • Parnes JR; Amgen, Thousand Oaks, California, USA.
  • Roskos L; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R and D, AstraZeneca, Gaithersburg, Maryland, USA.
J Clin Pharmacol ; 61(7): 901-912, 2021 07.
Article en En | MEDLINE | ID: mdl-33368307
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Antiasmáticos / Anticuerpos Monoclonales Humanizados Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Clin Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Antiasmáticos / Anticuerpos Monoclonales Humanizados Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: J Clin Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos