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Regulatory B cells in cancer.
Michaud, Daniel; Steward, Colleen R; Mirlekar, Bhalchandra; Pylayeva-Gupta, Yuliya.
Afiliación
  • Michaud D; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Steward CR; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Mirlekar B; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
  • Pylayeva-Gupta Y; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Immunol Rev ; 299(1): 74-92, 2021 01.
Article en En | MEDLINE | ID: mdl-33368346
Tumorigenesis proceeds through discrete steps where acquisition of genetic lesions and changes in the surrounding microenvironment combine to drive unrestricted neoplastic proliferation and metastasis. The ability of tumor-infiltrating immune cells to promote tumor growth via the provision of signals that enable tumor cell survival and proliferation as well as contribute to immune suppression is an active area of research. Recent efforts have provided us with mechanistic insights into how B cells can positively and negatively regulate immune responses. Negative regulation of immune responses in cancer can be mediated by regulatory B cells and is often a result of increased production of cytokines that can directly and indirectly affect anti-tumor immune function and cancer cell growth. Signals that lead to the expansion of regulatory B cells and the spectrum of their functional roles are not well understood and are the subject of active research by many groups. Here, we elaborate broadly on the history of regulatory B cells in cancer and summarize recent studies that have established genetic models for the study of regulatory B cell function and their potential for therapeutic intervention in the setting of solid cancers.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos B Reguladores / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Immunol Rev Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos B Reguladores / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Immunol Rev Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos