Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.

Thapa, Komal; Khan, Heena; Sharma, Uma; Grewal, Amarjot Kaur; Singh, Thakur Gurjeet

Thapa, Komal; Khan, Heena; Sharma, Uma; Grewal, Amarjot Kaur; Singh, Thakur Gurjeet.

Afiliación

Thapa K; Chitkara College of Pharmacy, Chitkara University, Punjab, India; Chitkara School of Pharmacy, Chitkara University, Himachal Pradesh, India.
Khan H; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Sharma U; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Grewal AK; Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Singh TG; Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address: gurjeet.singh@chitkara.edu.in.

Life Sci ; 267: 118975, 2021 Feb 15.

Article en En | MEDLINE | ID: mdl-33387580

Asunto(s)

Enfermedades Neurodegenerativas/tratamiento farmacológico; Enfermedades Neurodegenerativas/enzimología; Poli(ADP-Ribosa) Polimerasa-1/metabolismo; Animales; Enfermedades del Sistema Nervioso Central/tratamiento farmacológico; Enfermedades del Sistema Nervioso Central/metabolismo; Humanos; Terapia Molecular Dirigida; Enfermedades Neurodegenerativas/metabolismo; Poli(ADP-Ribosa) Polimerasa-1/antagonistas & inhibidores; Poli(ADP-Ribosa) Polimerasa-1/genética; Inhibidores de Poli(ADP-Ribosa) Polimerasas/farmacología

Palabras clave

ASK-JNK signalling; Caspases; NF-κB signalling; Neurodegenerative diseases; PARP (poly (ADP-ribose) polymerase); PARP-1 inhibitors; PI3K signalling; Parthanatos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Poli(ADP-Ribosa) Polimerasa-1 Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Life Sci Año: 2021 Tipo del documento: Article País de afiliación: India

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