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Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice.
Ling, Sikai; Yang, Shiqi; Hu, Xinde; Yin, Di; Dai, Yao; Qian, Xiaoqing; Wang, Dawei; Pan, Xiaoyong; Hong, Jiaxu; Sun, Xiaodong; Yang, Hui; Paludan, Soren Riis; Cai, Yujia.
Afiliación
  • Ling S; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
  • Yang S; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Hu X; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Yin D; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
  • Dai Y; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
  • Qian X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Wang D; National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Pan X; Key Laboratory of System Control and Information Processing (Ministry of Education), Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, China.
  • Hong J; Department of Ophthalmology and Vision Science, Shanghai Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
  • Sun X; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yang H; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Paludan SR; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Cai Y; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. yujia.cai@sjtu.edu.cn.
Nat Biomed Eng ; 5(2): 144-156, 2021 02.
Article en En | MEDLINE | ID: mdl-33398131
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lentivirus / Factor A de Crecimiento Endotelial Vascular / Sistemas CRISPR-Cas / Edición Génica / Proteína 9 Asociada a CRISPR / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Año: 2021 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lentivirus / Factor A de Crecimiento Endotelial Vascular / Sistemas CRISPR-Cas / Edición Génica / Proteína 9 Asociada a CRISPR / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Año: 2021 Tipo del documento: Article País de afiliación: China