Developmental Changes in Phosphate Homeostasis.
Rev Physiol Biochem Pharmacol
; 179: 117-138, 2021.
Article
en En
| MEDLINE
| ID: mdl-33398502
ABSTRACT
Phosphate is a multivalent ion critical for a variety of physiological functions including bone formation, which occurs rapidly in the developing infant. In order to ensure maximal bone mineralization, young animals must maintain a positive phosphate balance. To accomplish this, intestinal absorption and renal phosphate reabsorption are greater in suckling and young animals relative to adults. This review discusses the known intestinal and renal adaptations that occur in young animals in order to achieve a positive phosphate balance. Additionally, we discuss the ontogenic changes in phosphotropic endocrine signalling as it pertains to intestinal and renal phosphate handling, including several endocrine factors not always considered in the traditional dogma of phosphotropic endocrine signalling, such as growth hormone, triiodothyronine, and glucocorticoids. Finally, a proposed model of how these factors may contribute to achieving a positive phosphate balance during development is proposed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatos
/
Absorción Intestinal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
/
Infant
Idioma:
En
Revista:
Rev Physiol Biochem Pharmacol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá