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The association between migrant status and transition in an ultra-high risk for psychosis population.
O'Donoghue, Brian; Geros, Hellen; Sizer, Holly; Addington, Jean; Amminger, G Paul; Beaden, Carrie E; Cadenhead, Kristin S; Cannon, Tyrone D; Cornblatt, Barbara A; Berger, Gregor Emanuel; Chen, Eric Y H; de Haan, Lieuwe; Hartmann, Jessica A; Hickie, Ian B; Ising, Helga K; Lavoie, Suzie; Lin, Ashleigh; Markulev, Connie; Mathalon, Daniel H; McGlashan, Thomas H; Mifsud, Nathan G; Mossaheb, Nilufar; Nieman, Dorien H; Nordentoft, Merete; Perkins, Diana O; Riecher-Rössler, Anita; Schäfer, Miriam R; Schlögelhofer, Monika; Seidman, Larry J; Smesny, Stephan; Thompson, Andrew; Tsuang, Ming T; van der Gaag, Mark; Verma, Swapna; Walker, Elaine F; Wood, Stephen J; Woods, Scott W; Yuen, Hok Pan; Yung, Alison Ruth; McGorry, Patrick D; Nelson, Barnaby.
Afiliación
  • O'Donoghue B; Orygen, Melbourne, Australia. brian.odonoghue@orygen.org.au.
  • Geros H; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. brian.odonoghue@orygen.org.au.
  • Sizer H; Orygen, Melbourne, Australia.
  • Addington J; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Amminger GP; Orygen, Melbourne, Australia.
  • Beaden CE; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Cadenhead KS; Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
  • Cannon TD; Orygen, Melbourne, Australia.
  • Cornblatt BA; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Berger GE; Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
  • Chen EYH; Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
  • de Haan L; Department of Psychiatry, UCSD, San Diego, CA, USA.
  • Hartmann JA; Department of Psychology, Yale University, New Haven, CT, USA.
  • Hickie IB; Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA.
  • Ising HK; Child and Adolescent Psychiatric Service of the Canton of Zurich, Zürich, Switzerland.
  • Lavoie S; Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Lin A; Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
  • Markulev C; Orygen, Melbourne, Australia.
  • Mathalon DH; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • McGlashan TH; Brain and Mind Research Institute, University of Sydney, Sydney, Australia.
  • Mifsud NG; Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands.
  • Mossaheb N; Orygen, Melbourne, Australia.
  • Nieman DH; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Nordentoft M; Telethon Kids Institute, Perth, Australia.
  • Perkins DO; Orygen, Melbourne, Australia.
  • Riecher-Rössler A; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Schäfer MR; Department of Psychiatry, UCSF, San Francisco, CA, USA.
  • Schlögelhofer M; SFVA Medical Center, San Francisco, CA, USA.
  • Seidman LJ; Department of Psychiatry, Yale University, New Haven, CT, USA.
  • Smesny S; Orygen, Melbourne, Australia.
  • Thompson A; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Tsuang MT; Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
  • van der Gaag M; Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
  • Verma S; Psychiatric Centre Bispebjerg, Copenhagen, Denmark.
  • Walker EF; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Wood SJ; Psychiatric University Clinics Basel, Basel, Switzerland.
  • Woods SW; Orygen, Melbourne, Australia.
  • Yuen HP; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Yung AR; Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
  • McGorry PD; Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Nelson B; Massachusetts General Hospital, Boston, MA, USA.
Soc Psychiatry Psychiatr Epidemiol ; 56(6): 943-952, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33399885
ABSTRACT

PURPOSE:

Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder.

METHODS:

Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model.

RESULTS:

2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147-756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62-1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70-1.51).

CONCLUSIONS:

This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Migrantes Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Adult / Humans Idioma: En Revista: Soc Psychiatry Psychiatr Epidemiol Asunto de la revista: CIENCIAS SOCIAIS / EPIDEMIOLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Migrantes Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Adult / Humans Idioma: En Revista: Soc Psychiatry Psychiatr Epidemiol Asunto de la revista: CIENCIAS SOCIAIS / EPIDEMIOLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Australia