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Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
Bunis, Daniel G; Bronevetsky, Yelena; Krow-Lucal, Elisabeth; Bhakta, Nirav R; Kim, Charles C; Nerella, Srilaxmi; Jones, Norman; Mendoza, Ventura F; Bryson, Yvonne J; Gern, James E; Rutishauser, Rachel L; Ye, Chun Jimmie; Sirota, Marina; McCune, Joseph M; Burt, Trevor D.
Afiliación
  • Bunis DG; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
  • Bronevetsky Y; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Krow-Lucal E; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Bhakta NR; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Kim CC; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Nerella S; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Jones N; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Mendoza VF; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Bryson YJ; Division of Pediatric Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, Los Angeles, CA, USA.
  • Gern JE; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Rutishauser RL; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Ye CJ; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Fr
  • Sirota M; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, Division of Neonatology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: marina.sirota@ucsf.edu.
  • McCune JM; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: mike.mccune@gatesfoundation.org.
  • Burt TD; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, Division of Neonatology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: trevor.burt@duke.edu.
Cell Rep ; 34(1): 108573, 2021 01 05.
Article en En | MEDLINE | ID: mdl-33406429
ABSTRACT
Whereas the human fetal immune system is poised to generate immune tolerance and suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti-pathogen immune responses in post-natal life. It has been posited that cells of the adult immune system arise as a discrete ontological "layer" of hematopoietic stem-progenitor cells (HSPCs) and their progeny; evidence supporting this model in humans has, however, been inconclusive. Here, we combine bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and HSPCs from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurs progressively along a continuum of maturity-with a substantial degree of inter-individual variation at the time of birth-rather than via a transition between discrete waves. These findings have important implications for the design of strategies for prophylaxis against infection in the newborn and for the use of umbilical cord blood (UCB) in the setting of transplantation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Linfocitos / Linfocitos T / Células Mieloides / Análisis de la Célula Individual / Feto / Transcriptoma Tipo de estudio: Prognostic_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Linfocitos / Linfocitos T / Células Mieloides / Análisis de la Célula Individual / Feto / Transcriptoma Tipo de estudio: Prognostic_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos