Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation.
BMC Res Notes
; 14(1): 14, 2021 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-33413600
ABSTRACT
OBJECTIVE:
Standard rodent sepsis models as cecal ligation and puncture models (CLP) or cecal ligation and incision models (CLI) are frequently not suited experiments, mainly because they lack surgical repair, and they are difficult to control for severity. The colon ascendens stent peritonitis model (CASP) overcomes some of these limitations.RESULT:
Here we present our modification of the rodent CASP model, where severity of sepsis can be controlled by timing of surgical repair and treatment, and by diameter of the stent. Further, basic hemodynamic monitoring (blood pressure and heart rate) and frequent blood sampling can be achieved, which might guide further treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Peritonitis
/
Sepsis
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
BMC Res Notes
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suiza