The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.
Mamm Genome
; 32(1): 30-37, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33420513
ABSTRACT
Rift Valley fever (RVF) is an emerging viral zoonosis that primarily affects ruminants and humans. We have previously shown that wild-derived MBT/Pas mice are highly susceptible to RVF virus and that part of this phenotype is controlled by a locus located on distal Chromosome 11. Using congenic strains, we narrowed down the critical interval to a 530 kb region containing five protein-coding genes among which Rnf213 emerged as a potential candidate. We generated Rnf213-deficient mice by CRISPR/CAS9 on the C57BL/6 J background and showed that they were significantly more susceptible to RVF than control mice, with an average survival time post-infection reduced from 7 to 4 days. The human RNF213 gene had been associated with the cerebrovascular Moyamoya disease (MMD or MYMY) but the inactivation of this gene in the mouse resulted only in mild anomalies of the neovascularization. This study provides the first evidence that the Rnf213 gene may also impact the resistance to infectious diseases such as RVF.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fiebre del Valle del Rift
/
Virus de la Fiebre del Valle del Rift
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Adenosina Trifosfatasas
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Ubiquitina-Proteína Ligasas
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Interacciones Huésped-Patógeno
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Resistencia a la Enfermedad
Límite:
Animals
Idioma:
En
Revista:
Mamm Genome
Asunto de la revista:
GENETICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia