The Role of Inflammation in Crohn's Disease Recurrence after Surgical Treatment.
J Immunol Res
; 2020: 8846982, 2020.
Article
en En
| MEDLINE
| ID: mdl-33426097
ABSTRACT
INTRODUCTION:
Postoperative recurrence after surgery for Crohn's disease (CD) is virtually inevitable, and its mechanism is poorly known.AIM:
To review the numerous factors involved in CD postoperative recurrence (POR) pathogenesis, focusing on single immune system components as well as the immune system as a whole and highlighting the clinical significance in terms of preventive strategies and future perspectives.METHODS:
A systematic literature search on CD POR, followed by a review of the main findings.RESULTS:
The immune system plays a pivotal role in CD POR, with many different factors involved. Memory T-lymphocytes retained in mesenteric lymph nodes seem to represent the main driving force. New pathophysiology-based preventive strategies in the medical and surgical fields may help reduce POR rates. In particular, surgical strategies have already been developed and are currently under investigation.CONCLUSIONS:
POR is a complex phenomenon, whose driving mechanisms are gradually being unraveled. New preventive strategies addressing these mechanisms seem promising.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Crohn
/
Inflamación
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia