Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [<sup>177</sup>Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model.

Delage, Judith Anna; Faivre-Chauvet, Alain; Barbet, Jacques; Fierle, Julie Katrin; Schaefer, Niklaus; Coukos, George; Viertl, David; Dunn, Steven Mark; Gnesin, Silvano; Prior, John O

Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [¹⁷⁷Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model.

Delage, Judith Anna; Faivre-Chauvet, Alain; Barbet, Jacques; Fierle, Julie Katrin; Schaefer, Niklaus; Coukos, George; Viertl, David; Dunn, Steven Mark; Gnesin, Silvano; Prior, John O.

Afiliación

Delage JA; Radiopharmacy Unit, Department of Pharmacy, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Faivre-Chauvet A; CRCINA, INSERM 1232-CNRS ERL 6001, University of Angers, University of Nantes, 44000 Nantes, France.
Barbet J; Groupement d'Intérêt Public Arronax, F-44800 Saint-Herblain, France.
Fierle JK; LAbCore, Ludwig Institute for Cancer Research, Lausanne University Hospital and University of Lausanne, CH-1066 Epalinges, Switzerland.
Schaefer N; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Coukos G; Ludwig Institute for Cancer Research and Department of Oncology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Viertl D; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Dunn SM; LAbCore, Ludwig Institute for Cancer Research, Lausanne University Hospital and University of Lausanne, CH-1066 Epalinges, Switzerland.
Gnesin S; Institute of Radiation Physics, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Prior JO; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.

Pharmaceutics ; 13(1)2021 Jan 13.

Article en En | MEDLINE | ID: mdl-33451158

Palabras clave

177Lu radiolabeling; DOTA conjugation; TEM-1; biodistribution; fusion protein antibody; theranostic; tumor/liver ratio

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2021 Tipo del documento: Article País de afiliación: Suiza

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