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Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus.
Suda, Yukari; Nakashima, Toshihisa; Matsumoto, Hiroaki; Sato, Daisuke; Nagano, Satoshi; Mikata, Haruka; Yoshida, Sara; Tanaka, Kenichi; Hamada, Yusuke; Kuzumaki, Naoko; Narita, Minoru.
Afiliación
  • Suda Y; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Nakashima T; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Department of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Matsumoto H; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Sato D; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Nagano S; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Mikata H; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Yoshida S; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Tanaka K; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Hamada Y; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Kuzumaki N; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan. Electronic address: n-kuzumaki@hoshi.ac.jp.
  • Narita M; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara Shinagawa-ku, Tokyo, 142-8501, Japan; Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: narita@ho
Biochem Biophys Res Commun ; 541: 22-29, 2021 02 19.
Article en En | MEDLINE | ID: mdl-33461064
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Astrocitos / Senescencia Celular / Microglía / Receptor de Muerte Celular Programada 1 / Hipotálamo Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Astrocitos / Senescencia Celular / Microglía / Receptor de Muerte Celular Programada 1 / Hipotálamo Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article País de afiliación: Japón