Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis.

Kong, Duanyang; Munch, Maxime; Qiqige, Qiqige; Cooze, Christopher J C; Rotstein, Benjamin H; Lundgren, Rylan J

Kong, Duanyang; Munch, Maxime; Qiqige, Qiqige; Cooze, Christopher J C; Rotstein, Benjamin H; Lundgren, Rylan J.

Afiliación

Kong D; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Munch M; Department of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Qiqige Q; University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.
Cooze CJC; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Rotstein BH; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Lundgren RJ; Department of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

J Am Chem Soc ; 143(5): 2200-2206, 2021 02 10.

Article en En | MEDLINE | ID: mdl-33507731

ABSTRACT

ABSTRACT

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal-catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabeling of drug molecules and precursors with [11C]CO2 is demonstrated.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2021 Tipo del documento: Article País de afiliación: Canadá

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