In Silico Assessment of Class I Antiarrhythmic Drug Effects on <i>Pitx2</i>-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues.

Bai, Jieyun; Zhu, Yijie; Lo, Andy; Gao, Meng; Lu, Yaosheng; Zhao, Jichao; Zhang, Henggui

In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues.

Bai, Jieyun; Zhu, Yijie; Lo, Andy; Gao, Meng; Lu, Yaosheng; Zhao, Jichao; Zhang, Henggui.

Afiliación

Bai J; Department of Electronic Engineering, College of Information Science and Technology, Jinan University, Guangzhou 510632, China.
Zhu Y; Department of Electronic Engineering, College of Information Science and Technology, Jinan University, Guangzhou 510632, China.
Lo A; Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand.
Gao M; Department of Computer Science and Technology, College of Electrical Engineering and Information, Northeast Agricultural University, Harbin 150030, China.
Lu Y; Department of Electronic Engineering, College of Information Science and Technology, Jinan University, Guangzhou 510632, China.
Zhao J; Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand.
Zhang H; Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK.

Int J Mol Sci ; 22(3)2021 Jan 27.

Article en En | MEDLINE | ID: mdl-33514068

Asunto(s)

Arritmias Cardíacas/tratamiento farmacológico; Fibrilación Atrial/tratamiento farmacológico; Proteínas de Homeodominio/genética; Factores de Transcripción/genética; Animales; Antiarrítmicos/química; Antiarrítmicos/farmacología; Arritmias Cardíacas/genética; Arritmias Cardíacas/patología; Fibrilación Atrial/genética; Fibrilación Atrial/patología; Simulación por Computador; Disopiramida/química; Disopiramida/farmacología; Atrios Cardíacos/efectos de los fármacos; Atrios Cardíacos/patología; Humanos; Ratones; Propafenona/química; Propafenona/uso terapéutico; Quinidina/química; Quinidina/farmacología; Proteína del Homeodomínio PITX2

Palabras clave

Pitx2; action potential; atrial fibrillation; class I antiarrhythmic drugs; disopyramide; flecainide; in silico model; population of models; propafenone; quinidine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Fibrilación Atrial / Factores de Transcripción / Proteínas de Homeodominio Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: China

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