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Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability.
Wang, Bin; Pan, Rizhao; Zhu, Weiping; Xu, Yufang; Tian, Ye; Endo, Masayuki; Sugiyama, Hiroshi; Yang, Yangyang; Qian, Xuhong.
Afiliación
  • Wang B; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
  • Pan R; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
  • Zhu W; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
  • Xu Y; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
  • Tian Y; College of Engineering and Applied Science, Nanjing University, Nanjing, 210093, China.
  • Endo M; Department of Chemistry, Kyoto University, Kitashirakawa-Oiwakecho, 606-8502, Kyoto, Japan.
  • Sugiyama H; Department of Chemistry, Kyoto University, Kitashirakawa-Oiwakecho, 606-8502, Kyoto, Japan.
  • Yang Y; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
  • Qian X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn and State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Soft Matter ; 17(5): 1184-1188, 2021 Feb 15.
Article en En | MEDLINE | ID: mdl-33527954
ABSTRACT
A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanosferas Idioma: En Revista: Soft Matter Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanosferas Idioma: En Revista: Soft Matter Año: 2021 Tipo del documento: Article País de afiliación: China