Your browser doesn't support javascript.
loading
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Moquin, Stephanie A; Simon, Oliver; Karuna, Ratna; Lakshminarayana, Suresh B; Yokokawa, Fumiaki; Wang, Feng; Saravanan, Chandra; Zhang, Jin; Day, Craig W; Chan, Katherine; Wang, Qing-Yin; Lu, Siyan; Dong, Hongping; Wan, Kah Fei; Lim, Siew Pheng; Liu, Wei; Seh, Cheah Chen; Chen, Yen-Liang; Xu, Haoying; Barkan, David T; Kounde, Cyrille S; Sim, Wei Lin Sandra; Wang, Gang; Yeo, Hui-Quan; Zou, Bin; Chan, Wai Ling; Ding, Mei; Song, Jae-Geun; Li, Min; Osborne, Colin; Blasco, Francesca; Sarko, Christopher; Beer, David; Bonamy, Ghislain M C; Sasseville, Vito G; Shi, Pei-Yong; Diagana, Thierry T; Yeung, Bryan K S; Gu, Feng.
Afiliación
  • Moquin SA; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Simon O; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Karuna R; Novartis (Singapore) Pte Ltd, Singapore 117432, Singapore.
  • Lakshminarayana SB; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Yokokawa F; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Wang F; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Saravanan C; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Zhang J; Novartis Institutes for Biomedical Research, Translational Medicine: Preclinical Safety, Cambridge, MA 02139, USA.
  • Day CW; Novartis Institutes for Biomedical Research, Translational Medicine: Pharmacokinetics, East Hanover, NJ 07936, USA.
  • Chan K; Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA.
  • Wang QY; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Lu S; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Dong H; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Wan KF; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Lim SP; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Liu W; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Seh CC; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Chen YL; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Xu H; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Barkan DT; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Kounde CS; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Sim WLS; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Wang G; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Yeo HQ; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Zou B; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Chan WL; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Ding M; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Song JG; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Li M; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Osborne C; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Blasco F; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Sarko C; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Beer D; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Bonamy GMC; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Sasseville VG; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Shi PY; Novartis Institutes for Biomedical Research, Translational Medicine: Preclinical Safety, Cambridge, MA 02139, USA.
  • Diagana TT; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore.
  • Yeung BKS; Novartis Institute for Tropical Diseases, Emeryville, CA 94608, USA.
  • Gu F; Novartis Institute for Tropical Diseases, Singapore 138670, Singapore. bryan.yeung@rightfund.org feng.gu@novartis.com.
Sci Transl Med ; 13(579)2021 02 03.
Article en En | MEDLINE | ID: mdl-33536278
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos