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Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples.
Pascoal, Lívia Bitencourt; Rodrigues, Patrícia Brito; Genaro, Lívia Moreira; Gomes, Arilson Bernardo Dos Santos Pereira; Toledo-Teixeira, Daniel Augusto; Parise, Pierina Lorencini; Bispo-Dos-Santos, Karina; Simeoni, Camila Lopes; Guimarães, Paula Veri; Buscaratti, Lucas Ildefonso; Elston, João Gabriel De Angeli; Marques-Souza, Henrique; Martins-de-Souza, Daniel; Ayrizono, Maria De Lourdes Setsuko; Velloso, Lício Augusto; Proenca-Modena, José Luiz; Moraes-Vieira, Pedro Manoel Mendes; Mori, Marcelo Alves Silva; Farias, Alessandro Santos; Vinolo, Marco Aurélio Ramirez; Leal, Raquel Franco.
Afiliación
  • Pascoal LB; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Rodrigues PB; Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Genaro LM; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Gomes ABDSP; Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Toledo-Teixeira DA; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Parise PL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Bispo-Dos-Santos K; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Simeoni CL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Guimarães PV; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Buscaratti LI; Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Elston JGA; Brazilian Laboratory on Silencing Technologies (Blast), Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Marques-Souza H; Brazilian Laboratory on Silencing Technologies (Blast), Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Martins-de-Souza D; Brazilian Laboratory on Silencing Technologies (Blast), Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Ayrizono MLS; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP) , Campinas, Brazil.
  • Velloso LA; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Proenca-Modena JL; Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Moraes-Vieira PMM; Laboratory of Cell Signaling, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Mori MAS; Obesity and Comorbidities Research Center (OCRC), University of Campinas (UNICAMP) , Campinas, Brazil.
  • Farias AS; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP) , Campinas, Brazil.
  • Vinolo MAR; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP) , Campinas, Brazil.
  • Leal RF; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP) , Campinas, Brazil.
Gut Microbes ; 13(1): 1-9, 2021.
Article en En | MEDLINE | ID: mdl-33550892
Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Volátiles / Microbioma Gastrointestinal / COVID-19 / Mucosa Intestinal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Microbes Año: 2021 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Volátiles / Microbioma Gastrointestinal / COVID-19 / Mucosa Intestinal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Microbes Año: 2021 Tipo del documento: Article País de afiliación: Brasil