Your browser doesn't support javascript.
loading
Isolation and characterization of a novel flavanone glycoside from an endemic plant Haplanthodes neilgherryensis.
Singh, Ruchi; Dhiman, Mini; Saklani, Arvind; Immanuel Selvaraj, C; Kate, Abhijeet S.
Afiliación
  • Singh R; Natural Products-Botany, Piramal Enterprises Ltd, Mumbai 400070, India.
  • Dhiman M; School of Biosciences and Technology, Vellore Institute of Technology University, Vellore 632014, India.
  • Saklani A; Natural Products-Bioactivity Lab, Piramal Enterprises Ltd, Mumbai 400070, India.
  • Immanuel Selvaraj C; Natural Products-Botany, Piramal Enterprises Ltd, Mumbai 400070, India.
  • Kate AS; School of Biosciences and Technology, Vellore Institute of Technology University, Vellore 632014, India.
J Asian Nat Prod Res ; 24(1): 96-101, 2022 Jan.
Article en En | MEDLINE | ID: mdl-33555214
The chemical characterization study of an endemic plant, Haplanthodes neilgherryensisis (Wight) R.B. Majumdar from Western Ghats of India, resulted in to the isolation of a new flavanone glycoside, 5-hydroxy-7-methoxy-8-O-ß-D-glucopyranosyl-2S-flavanone (1), along with 3 known flavonoids, 7-O-methyl dihydrowogonin (2), 7-O-methyl wogonin (3), andrographidine C (4). The structure of 1 was elucidated by using 1 D and 2 D NMR and HRMS experimental data, while for the known compounds, 1H NMR and mass spectrometry data were compared with the reported literature. Compound 1 was tested in vitro to check the improvement in uptake of glucose by the L6 rat skeletal muscle tissues and the observed EC50 value was 5.8 µM, while rosiglitazone showed EC50 of 2.7 µM.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acanthaceae / Flavanonas / Glicósidos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acanthaceae / Flavanonas / Glicósidos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: India