Your browser doesn't support javascript.
loading
Catalytic Enantioselective Desymmetrizing Fischer Indolization through Dynamic Kinetic Resolution.
Ghosh, Biki; Balhara, Reena; Jindal, Garima; Mukherjee, Santanu.
Afiliación
  • Ghosh B; Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
  • Balhara R; Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
  • Jindal G; Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
  • Mukherjee S; Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
Angew Chem Int Ed Engl ; 60(16): 9086-9092, 2021 04 12.
Article en En | MEDLINE | ID: mdl-33555647
ABSTRACT
The first catalytic enantioselective Fischer indolization of prochiral diketones containing enantiotopic carbonyl groups is developed and shown to proceed through dynamic kinetic resolution (DKR). Catalyzed by the combination of a spirocyclic chiral phosphoric acid and ZnCl2 (Lewis acid assisted Brønsted acid), this direct approach combines 2,2-disubstituted cyclopentane-1,3-diones with N-protected phenylhydrazines to furnish cyclopenta[b]indole derivatives containing an all-carbon quaternary stereocenter with good to excellent enantioselectivities.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: India