A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques.
Emerg Microbes Infect
; 10(1): 342-355, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-33555988
ABSTRACT
The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vacunas de ADN
/
Vacunas de Subunidad
/
Glicoproteína de la Espiga del Coronavirus
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Vacunas contra la COVID-19
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COVID-19
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Emerg Microbes Infect
Año:
2021
Tipo del documento:
Article