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Antioxidants Promote Intestinal Tumor Progression in Mice.
Zou, Zhiyuan V; Le Gal, Kristell; El Zowalaty, Ahmed E; Pehlivanoglu, Lara E; Garellick, Viktor; Gul, Nadia; Ibrahim, Mohamed X; Bergh, Per-Olof; Henricsson, Marcus; Wiel, Clotilde; Akyürek, Levent M; Bergo, Martin O; Sayin, Volkan I; Lindahl, Per.
Afiliación
  • Zou ZV; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Le Gal K; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • El Zowalaty AE; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Pehlivanoglu LE; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Garellick V; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Gul N; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Ibrahim MX; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Bergh PO; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Henricsson M; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Wiel C; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Akyürek LM; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Bergo MO; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Sayin VI; Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Lindahl P; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
Antioxidants (Basel) ; 10(2)2021 Feb 04.
Article en En | MEDLINE | ID: mdl-33557356
ABSTRACT
Dietary antioxidants and supplements are widely used to protect against cancer, even though it is now clear that antioxidants can promote tumor progression by helping cancer cells to overcome barriers of oxidative stress. Although recent studies have, in great detail, explored the role of antioxidants in lung and skin tumors driven by RAS and RAF mutations, little is known about the impact of antioxidant supplementation on other cancers, including Wnt-driven tumors originating from the gut. Here, we show that supplementation with the antioxidants N-acetylcysteine (NAC) and vitamin E promotes intestinal tumor progression in the ApcMin mouse model for familial adenomatous polyposis, a hereditary form of colorectal cancer, driven by Wnt signaling. Both antioxidants increased tumor size in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation. Importantly, NAC treatment accelerated tumor progression at plasma concentrations comparable to those obtained in human subjects after prescription doses of the drug. These results demonstrate that antioxidants play an important role in the progression of intestinal tumors, which may have implications for patients with or predisposed to colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Suecia