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Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling.
Adamopoulos, Christos; Ahmed, Tamer A; Tucker, Maxwell R; Ung, Peter M U; Xiao, Min; Karoulia, Zoi; Amabile, Angelo; Wu, Xuewei; Aaronson, Stuart A; Ang, Celina; Rebecca, Vito W; Brown, Brian D; Schlessinger, Avner; Herlyn, Meenhard; Wang, Qi; Shaw, David E; Poulikakos, Poulikos I.
Afiliación
  • Adamopoulos C; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Ahmed TA; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Tucker MR; D. E. Shaw Research, New York, New York.
  • Ung PMU; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Xiao M; The Wistar Institute, Philadelphia, Pennsylvania.
  • Karoulia Z; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Amabile A; Department of Genetics and Genomics Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Wu X; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Aaronson SA; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Ang C; Department of Medicine, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Rebecca VW; The Wistar Institute, Philadelphia, Pennsylvania.
  • Brown BD; Department of Genetics and Genomics Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Schlessinger A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Herlyn M; The Wistar Institute, Philadelphia, Pennsylvania.
  • Wang Q; D. E. Shaw Research, New York, New York.
  • Shaw DE; D. E. Shaw Research, New York, New York. poulikos.poulikakos@mssm.edu David.Shaw@DEShawResearch.com.
  • Poulikakos PI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York.
Cancer Discov ; 11(7): 1716-1735, 2021 07.
Article en En | MEDLINE | ID: mdl-33568355

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Melanoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Discov Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Melanoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Discov Año: 2021 Tipo del documento: Article