Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules.

Mercier, Anne E; Prudent, Renaud; Pepper, Michael S; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechère, Laurence; Joubert, Anna M

Mercier, Anne E; Prudent, Renaud; Pepper, Michael S; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechère, Laurence; Joubert, Anna M.

Afiliación

Mercier AE; Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Prudent R; Institute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.
Pepper MS; Institute for Cellular and Molecular Medicine, Department of Immunology, School of Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
De Koning L; RPPA Platform, Institut Curie Centre de Recherche, PSL Research University, Paris 75248, France.
Nolte E; Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Peronne L; Institute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.
Nel M; Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Lafanechère L; Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Joubert AM; Institute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.

Molecules ; 26(3)2021 Jan 29.

Article en En | MEDLINE | ID: mdl-33572896

Asunto(s)

Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Neoplasias de la Mama/tratamiento farmacológico; Estrona/farmacología; Neoplasias del Cuello Uterino/tratamiento farmacológico; Antineoplásicos/farmacología; Apoptosis/genética; Autofagia/genética; Neoplasias de la Mama/patología; Muerte Celular/efectos de los fármacos; Muerte Celular/genética; Línea Celular Tumoral; Estrenos/farmacología; Estrona/análogos & derivados; Estrona/química; Femenino; Células HeLa; Humanos; Microtúbulos/química; Metástasis de la Neoplasia; Transducción de Señal/efectos de los fármacos; Sulfonamidas/farmacología; Neoplasias del Cuello Uterino/patología

Palabras clave

2-methoxyestradiol analogues; JNK; anti-cancer; apoptosis; autophagy; cell cycle arrest; microtubules; mitochondrial membrane potential; p27Kip1; reactive oxygen species

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Neoplasias de la Mama / Neoplasias del Cuello Uterino / Apoptosis / Estrona Límite: Female / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica

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