Platinum concentrations in human autopsy tumor samples.
Am J Clin Oncol
; 11(2): 152-8, 1988 Apr.
Article
en En
| MEDLINE
| ID: mdl-3358362
ABSTRACT
Platinum concentrations were determined in autopsy tumor samples obtained from 27 patients who had received cisplatin 40-1,029 mg/m2 from 0 to 240 days antemortem. Liver metastases had significantly higher platinum concentrations than did tumors in other sites (p less than 0.005). Platinum concentrations in liver metastases were similar to platinum concentrations in normal liver. Platinum concentrations in gliomas and brain metastases were similar to platinum concentrations in other extrahepatic tumors. Platinum concentration generally decreased with increasing distance into brain from tumor. By multiple stepwise linear regression analysis, the factors that were independently most closely associated with tumor platinum concentration were time from last cisplatin treatment, cumulative lifetime dose of cisplatin, route of cisplatin administration (intraarterial vs. other), and site of tumor deposit (liver vs. other) (r = 0.69, p less than 0.001). Patients whose tumors had responded to cisplatin-containing regimens had mean tumor platinum concentrations that were higher than the mean tumor platinum concentrations in patients whose tumors had not responded to cisplatin (p less than 0.05).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Platino (Metal)
/
Cisplatino
/
Neoplasias
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Clin Oncol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Canadá