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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
McNae, Iain W; Kinkead, James; Malik, Divya; Yen, Li-Hsuan; Walker, Martin K; Swain, Chris; Webster, Scott P; Gray, Nick; Fernandes, Peter M; Myburgh, Elmarie; Blackburn, Elizabeth A; Ritchie, Ryan; Austin, Carol; Wear, Martin A; Highton, Adrian J; Keats, Andrew J; Vong, Antonio; Dornan, Jacqueline; Mottram, Jeremy C; Michels, Paul A M; Pettit, Simon; Walkinshaw, Malcolm D.
Afiliación
  • McNae IW; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Kinkead J; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Malik D; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Yen LH; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Walker MK; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK.
  • Swain C; Cambridge MedChem Consulting, Cambridge, UK.
  • Webster SP; Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.
  • Gray N; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Fernandes PM; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Myburgh E; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK.
  • Blackburn EA; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Ritchie R; Institute of Infection Immunity and Inflammation, College of Medical Veterinary Life-Sciences, University of Glasgow, Glasgow, UK.
  • Austin C; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK.
  • Wear MA; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Highton AJ; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK.
  • Keats AJ; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK.
  • Vong A; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK.
  • Dornan J; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Mottram JC; York Biomedical Research Institute, Department of Biology, University of York, York, UK.
  • Michels PAM; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
  • Pettit S; Selcia Ltd., Fyfield Business and Research Park, Fyfield Road, Ongar, Essex, UK. simon.pettit@selcia.com.
  • Walkinshaw MD; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK. m.walkinshaw@ed.ac.uk.
Nat Commun ; 12(1): 1052, 2021 02 16.
Article en En | MEDLINE | ID: mdl-33594070
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trypanosoma / Tripanosomiasis Africana / Fosfofructoquinasas / Inhibidores de Proteínas Quinasas / Glucólisis Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trypanosoma / Tripanosomiasis Africana / Fosfofructoquinasas / Inhibidores de Proteínas Quinasas / Glucólisis Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido