The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice.
Behav Pharmacol
; 32(5): 448-452, 2021 08 01.
Article
en En
| MEDLINE
| ID: mdl-33595957
ABSTRACT
Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aprendizaje Inverso
/
Agonistas del Receptor de Serotonina 5-HT2
/
Trastorno Depresivo Resistente al Tratamiento
Límite:
Animals
Idioma:
En
Revista:
Behav Pharmacol
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Dinamarca