HDN-1 induces cell differentiation toward apoptosis in promyelocytic leukemia cells depending on its selective effect on client proteins of Hsp90.

Qi, Xin; Zhang, Xintong; Liu, Xiaochun; Tang, Wei; Dai, Jiajia; Chen, Ao; Lin, Qian; Zhu, Tianjiao; Li, Jing

Qi, Xin; Zhang, Xintong; Liu, Xiaochun; Tang, Wei; Dai, Jiajia; Chen, Ao; Lin, Qian; Zhu, Tianjiao; Li, Jing.

Afiliación

Qi X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Zhang X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Liu X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Tang W; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Dai J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Chen A; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Lin Q; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Zhu T; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China; Open Studio for Druggability Research of Marine Natural Products, Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Sci
Li J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China; Open Studio for Druggability Research of Marine Natural Products, Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Sci

Toxicol Appl Pharmacol ; 417: 115459, 2021 04 15.

Article en En | MEDLINE | ID: mdl-33609515

Asunto(s)

Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Diferenciación Celular/efectos de los fármacos; Dicetopiperazinas/farmacología; Disulfuros/farmacología; Granulocitos/efectos de los fármacos; Proteínas HSP90 de Choque Térmico/antagonistas & inhibidores; Leucemia Promielocítica Aguda/tratamiento farmacológico; Benzoquinonas/farmacología; Proteína beta Potenciadora de Unión a CCAAT/genética; Proteína beta Potenciadora de Unión a CCAAT/metabolismo; Linaje de la Célula; Subunidad alfa 2 del Factor de Unión al Sitio Principal/genética; Subunidad alfa 2 del Factor de Unión al Sitio Principal/metabolismo; Regulación Leucémica de la Expresión Génica; Granulocitos/metabolismo; Granulocitos/patología; Células HL-60; Proteínas HSP90 de Choque Térmico/genética; Proteínas HSP90 de Choque Térmico/metabolismo; Humanos; Lactamas Macrocíclicas/farmacología; Leucemia Promielocítica Aguda/genética; Leucemia Promielocítica Aguda/metabolismo; Leucemia Promielocítica Aguda/patología; Proteínas de Fusión Oncogénica/genética; Proteínas de Fusión Oncogénica/metabolismo; Proteína 1 Compañera de Translocación de RUNX1/genética; Proteína 1 Compañera de Translocación de RUNX1/metabolismo

Palabras clave

Apoptosis; Client protein; Differentiation; HDN-1; Hsp90; Selectivity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Promielocítica Aguda / Diferenciación Celular / Apoptosis / Proteínas HSP90 de Choque Térmico / Disulfuros / Dicetopiperazinas / Granulocitos / Antineoplásicos Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2021 Tipo del documento: Article

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