Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts.

Tachi, Junko; Onuma, Takashi; Yamaguchi, Shinobu; Kim, Woo; Hioki, Tomoyuki; Matsushima-Nishiwaki, Rie; Tanabe, Kumiko; Tokuda, Haruhiko; Kozawa, Osamu; Iida, Hiroki

Tachi, Junko; Onuma, Takashi; Yamaguchi, Shinobu; Kim, Woo; Hioki, Tomoyuki; Matsushima-Nishiwaki, Rie; Tanabe, Kumiko; Tokuda, Haruhiko; Kozawa, Osamu; Iida, Hiroki.

Afiliación

Tachi J; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Onuma T; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Yamaguchi S; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Kim W; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Hioki T; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Matsushima-Nishiwaki R; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tanabe K; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tokuda H; Department of Dermatology, Kizawa Memorial Hospital, Minokamo 505-8503, Japan.
Kozawa O; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Iida H; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Biochem Cell Biol ; 99(5): 578-586, 2021 10.

Article en En | MEDLINE | ID: mdl-33646885

Asunto(s)

Proteína Morfogenética Ósea 4/antagonistas & inhibidores; Clorhidrato de Duloxetina/farmacología; Osteoblastos/efectos de los fármacos; Osteoprotegerina/antagonistas & inhibidores; Células 3T3; Animales; Proteína Morfogenética Ósea 4/metabolismo; Células Cultivadas; Relación Dosis-Respuesta a Droga; Ratones; Osteoblastos/metabolismo; Osteoprotegerina/metabolismo; Transducción de Señal/efectos de los fármacos; Proteína Smad1/antagonistas & inhibidores; Proteína Smad1/metabolismo; Proteína Smad5/antagonistas & inhibidores; Proteína Smad5/metabolismo; Proteína Smad8/antagonistas & inhibidores; Proteína Smad8/metabolismo

Palabras clave

SMAD; bone morphogenetic protein; duloxetine; duloxétine; osteoblast; osteoprotegerin; ostéoblaste; ostéoprotégérine; protéine morphogénétique osseuse

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoblastos / Osteoprotegerina / Proteína Morfogenética Ósea 4 / Clorhidrato de Duloxetina Límite: Animals Idioma: En Revista: Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Japón

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