Transcription factor competition at the Î³-globin promoters controls hemoglobin switching.

Liu, Nan; Xu, Shuqian; Yao, Qiuming; Zhu, Qian; Kai, Yan; Hsu, Jonathan Y; Sakon, Phraew; Pinello, Luca; Yuan, Guo-Cheng; Bauer, Daniel E; Orkin, Stuart H

Liu, Nan; Xu, Shuqian; Yao, Qiuming; Zhu, Qian; Kai, Yan; Hsu, Jonathan Y; Sakon, Phraew; Pinello, Luca; Yuan, Guo-Cheng; Bauer, Daniel E; Orkin, Stuart H.

Afiliación

Liu N; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Xu S; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Yao Q; Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zhu Q; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kai Y; Molecular Pathology Unit & Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hsu JY; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Sakon P; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Pinello L; Molecular Pathology Unit & Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yuan GC; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Bauer DE; Molecular Pathology Unit & Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Orkin SH; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

Nat Genet ; 53(4): 511-520, 2021 04.

Article en En | MEDLINE | ID: mdl-33649594

Asunto(s)

Factor de Unión a CCAAT/química; Hemoglobina Fetal/genética; Hemoglobina A/genética; Regiones Promotoras Genéticas; Proteínas Represoras/química; gamma-Globinas/química; Secuencia de Bases; Sitios de Unión; Unión Competitiva; Factor de Unión a CCAAT/genética; Factor de Unión a CCAAT/metabolismo; Eritropoyesis/genética; Hemoglobina Fetal/metabolismo; Edición Génica/métodos; Regulación de la Expresión Génica; Células HEK293; Hemoglobina A/metabolismo; Humanos; Modelos Moleculares; Cultivo Primario de Células; Unión Proteica; Conformación Proteica en Hélice alfa; Conformación Proteica en Lámina beta; Dominios y Motivos de Interacción de Proteínas; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Células Madre; Globinas beta/química; Globinas beta/genética; Globinas beta/metabolismo; gamma-Globinas/genética; gamma-Globinas/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Hemoglobina Fetal / Hemoglobina A / Regiones Promotoras Genéticas / Factor de Unión a CCAAT / Gamma-Globinas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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