Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides.
Chem Commun (Camb)
; 57(26): 3283-3286, 2021 Apr 04.
Article
en En
| MEDLINE
| ID: mdl-33651072
ABSTRACT
SARS-CoV-2 Spike protein RBD interacts with the hACE2 receptor to initiate cell entry and infection. We set out to develop lactam-based i,i + 4 stapled hACE2 peptides targeting SARS-CoV-2. In vitro screening demonstrates the inhibition of the Spike protein RBD-hACE2 complex formation by the hACE221-55A36K-F40E stapled peptide (IC50 3.6 µM, Kd 2.1 µM), suggesting that hACE2 peptidomimetics could form the basis for the development of anti-COVID-19 therapeutics.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Glicoproteína de la Espiga del Coronavirus
/
Enzima Convertidora de Angiotensina 2
/
SARS-CoV-2
/
COVID-19
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Dinamarca