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Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction.
Hanff, Thomas C; Cohen, Jordana B; Zhao, Lei; Javaheri, Ali; Zamani, Payman; Prenner, Stuart B; Rietzschel, Ernst; Jia, Yi; Walsh, Alice; Maranville, Joseph; Wang, Zhaoqing; Adam, Leonard; Ramirez-Valle, Francisco; Schafer, Peter; Seiffert, Dietmar; Gordon, David A; Cvijic, Mary E; Cappola, Thomas P; Chirinos, Julio A.
Afiliación
  • Hanff TC; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Cohen JB; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zhao L; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Javaheri A; Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zamani P; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Prenner SB; Division of Cardiovascular Medicine, Washington University School of Medicine St. Louis, Missouri, USA.
  • Rietzschel E; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jia Y; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Walsh A; Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium.
  • Maranville J; SomaLogic, Boulder, Colorado, USA.
  • Wang Z; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Adam L; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Ramirez-Valle F; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Schafer P; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Seiffert D; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Gordon DA; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Cvijic ME; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Cappola TP; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Chirinos JA; Bristol-Myers Squibb, Princeton, New Jersey, USA.
JACC Basic Transl Sci ; 6(2): 89-99, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33665511
ABSTRACT
Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos